TABLE 1.

1,2-Dithiole-3-(thi)one compounds tested as FabH inhibitors in this study^a

^aCompounds 1 to 4 were identified and obtained from NCI during the initial screening process. Compound 5 was identified in a second search and obtained from NCI. The remaining compounds were synthesized. Compounds 1, 3, and 5 have previously been referred to as HR19, HR12 (RWJ-3981), and HR45, respectively (4, 26, 53).

^bFor compound 1, R₁ = R₂ = phenyl. For compound 2, R₁ = R₂ = CH₂CH₂Ph.