TABLE 3.
IC50 values of 1,2-dithiole-3-(thi)one inhibitors for saFabH
| Inhibitor | IC50 (μM)a
|
|
|---|---|---|
| Preincubation | No preincubation | |
| 3 | 0.983 ± 0.041 | 1.92 ± 0.17 (2) |
| 5 | 0.156 ± 0.010 | 2.25 ± 0.18 (14) |
| 6 | 0.109 ± 0.028 | 3.19 ± 0.43 (30) |
| 7 | 26.0 ± 4.9 | 31.0 ± 5.1 |
| 8 | 22.4 ± 4.6 | 22.0 ± 2.8 |
| 9 | 50.5 ± 11.8 | 51.9 ± 9.3 |
| 10 | 35.2 ± 3.0 | 32.2 ± 3.9 |
| 11 | 102 ± 11 | ND |
| 12 | 15.68 ± 0.54 | 30.0 ± 4.6 (2) |
| 13 | 9.3 ± 1.5 | 29.2 ± 2.1 (3) |
| 14 | >100 | >100 |
| 15 | >100 | >100 |
a
Assays for IC50 values were conducted with a 15-min preincubation or without preincubation. For values obtained without preincubation, the fold differences from values obtained with preincubation are shown in parentheses. ND, not determined.