TABLE 1.
Top 30 HIV-1 PI resistance patterns in 2,795 sequences from 2,275 persons with PI resistance mutations, 1997 to 2003
| Mutation pattern | No. (%) of sequencesa | No. of personsa | Cumulative % | Susceptibility to drug (foldn)b
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| NFV | SQV | IDV | RTV | APV | LPV | ATV | ||||
| D30N, N88D | 249 (8.9) | 210 | 8.9 | 5218 | 2.017 | 1.718 | 1.418 | 0.915 | 0.95 | 3.610 |
| L90M | 245 (8.8) | 206 | 17.7 | 3.29 | 1.410 | 1.310 | 2.610 | 1.26 | 0.33 | 3.02 |
| D30N | 130 (4.7) | 117 | 22.3 | 1410 | 0.510 | 0.910 | 0.610 | 0.58 | 0.62 | 1.85 |
| M46I, L90M | 89 (3.2) | 71 | 25.5 | 8.09 | 2.19 | 118 | 7.07 | 4.86 | 2.62 | 2.11 |
| G73S, L90M | 66 (2.4) | 54 | 27.9 | 274 | 9.24 | 7.94 | 5.34 | 1.34 | 1.33 | 2.01 |
| I54V, V82A, L90M | 60 (2.1) | 45 | 30.0 | 379 | 7.99 | 169 | 839 | 3.07 | 206 | 5.03 |
| L24I, M46L, I54V, V82A | 52 (1.9) | 35 | 31.9 | 396 | 7.16 | 205 | 804 | 4.04 | 343 | 191 |
| V82I | 51 (1.8) | 40 | 33.7 | 3.65 | 1.35 | 0.75 | 1.75 | 1.15 | 0.83 | 1.32 |
| G73S, I84V, L90M | 50 (1.8) | 41 | 35.5 | 343 | 703 | 193 | 443 | 4.52 | 7.23 | 151 |
| M46L, I54V, V82A, L90M | 49 (1.8) | 34 | 37.2 | 394 | 9.14 | 224 | 784 | 5.64 | 332 | |
| I84V, L90M | 39 (1.4) | 31 | 38.6 | 196 | 186 | 9.66 | 175 | 3.86 | 3.14 | 10.01 |
| M46I, N88S | 37 (1.3) | 30 | 40.0 | 197 | 1.47 | 6.17 | 1.77 | 0.26 | 0.81 | |
| M46I, G73S, L90M | 31 (1.1) | 26 | 41.1 | 223 | 3.43 | 8.33 | 4.43 | 1.62 | 3.03 | |
| I54V, V82A | 30 (1.1) | 29 | 42.1 | 129 | 1.49 | 8.39 | 288 | 3.07 | 2.31 | 6.04 |
| M46L | 29 (1.0) | 24 | 43.2 | 4.41 | 0.91 | 2.81 | 3.11 | 1.41 | 1.71 | |
| M46I, I84V, L90M | 29 (1.0) | 22 | 44.2 | 165 | 10.05 | 9.75 | 194 | 5.04 | 7.94 | |
| M46I | 26 (0.9) | 21 | 45.1 | 3.43 | 0.83 | 7.83 | 5.93 | 2.23 | 6.91 | |
| V82A | 26 (0.9) | 20 | 46.1 | 3.41 | 0.91 | 2.71 | 4.01 | 1.71 | 4.71 | 1.91 |
| M46I, I54V, V82A, L90M | 26 (0.9) | 18 | 47.0 | 752 | 232 | 372 | 1482 | 112 | 641 | |
| M46I, G73S, I84V, L90M | 24 (0.9) | 19 | 47.9 | 623 | 883 | 533 | 433 | 113 | 213 | 242 |
| D30N, N88D, L90M | 21 (0.8) | 20 | 48.6 | 7410 | 5.410 | 3.010 | 3.510 | 1.310 | 4.01 | |
| N88S | 21 (0.8) | 19 | 49.4 | 8.913 | 1.213 | 2.513 | 0.813 | 0.113 | 0.51 | 10.02 |
| G48V, I54V, V82A | 21 (0.8) | 15 | 50.1 | 283 | 1473 | 253 | 413 | 3.03 | 323 | 293 |
| V32I, M46I, V82A, L90M | 20 (0.7) | 14 | 50.8 | 252 | 4.52 | 272 | 452 | 142 | 122 | 202 |
| L24I, M46I, I54V, V82A | 18 (0.6) | 15 | 51.5 | 146 | 1.46 | 195 | 503 | 2.13 | 171 | |
| F53L, I54V, V82A, L90M | 18 (0.6) | 13 | 52.1 | 352 | 242 | 142 | 1072 | 3.12 | 302 | |
| L24I, M46L, V82A | 18 (0.6) | 12 | 52.8 | 6.11 | 1.31 | 7.41 | 451 | 5.81 | 7.01 | |
| M46L, V82A | 17 (0.6) | 12 | 53.4 | 5.52 | 1.12 | 6.32 | 132 | 4.52 | 6.62 | 2.52 |
| M46L, L90M | 17 (0.6) | 11 | 54.0 | 122 | 3.32 | 8.82 | 7.12 | 4.12 | 4.01 | |
| D30N, M46I, N88D | 15 (0.5) | 15 | 54.5 | 251 | 0.91 | 1.21 | 1.01 | 0.81 | ||
a
Of 4,183 persons, 2,275 had 2,795 mutant sequences with 553 different PI mutation patterns. The top 30 patterns accounted for 54.5% of 2,795 mutant sequences.
b
Median susceptibility results (n-fold) for isolates with matching patterns of mutations. The subscript is the number of samples for which susceptibility results are available. Results that are ≥2.5-fold the susceptibility of the wild-type control are shown in bold. Abbreviations: NFV, nelfinavir; SQV, saquinavir; IDV, indinavir; RTV, ritonavir; APV, amprenavir; LPV, lopinavir; ATV, atazanavir.