Table 1. Distribution of three SNPs in PARP-1 gene in Hashimoto thyroiditis.
| Genotype/allele | Cases, n (%) | Controls, n (%) | OR (95% CI) | P-value |
|---|---|---|---|---|
| rs1136410 | 141 | 150 | ||
| TT (Val/Val)a | 98 (70) | 77 (51) | 1 | |
| TC (Val/Ala) | 31 (21) | 61 (41) | 2.504 (1.48–4.23) | 0.001 |
| CC (Ala/Ala) | 12 (9) | 12 (8) | 1.273 (0.54–2.99) | 0.579 |
| T (Val) allele frequency | 227 (81) | 215 (72) | 1 | |
| C (Ala) allele frequency | 55 (19) | 85 (28) | 1.632 (1.1–2.403) | 0.013 |
| rs2793378 | 141 | 150 | ||
| CC | 62 (44) | 60 (40) | 1 | |
| CT | 62 (44) | 65 (43) | 0.92 (0.56–1.52) | 0.752 |
| TT | 17 (12) | 25 (17) | 0.66 (0.32–1.34) | 0.247 |
| C allele frequency | 186 (66) | 185 (62) | 1 | |
| T allele frequency | 96 (34) | 115 (38) | 0.84 (0.47–1.50) | 0.556 |
| rs7527192 | 141 | 150 | ||
| GG | 75 (53) | 60 (40) | 1 | |
| GA | 62 (44) | 81 (54) | 1.633 (1.017–2.623) | 0.042 |
| AA | 4 (3) | 9 (6) | 2.813 (0.826–9.581) | 0.087 |
| G allele frequency | 212 (75) | 201 (67) | 1 | |
| A allele frequency | 70 (25) | 99 (33) | 1.492 (1.039–2.142) | 0.03 |
Abbreviations:
CI, confidence intervals: OR, odds ratios.
a
The corresponding amino acids of each genotypes of rs1136410 polymorphism were given in parentheses.
The differences resulting from the genotypes were determined by proceeding χ2-test. P value after Bonferroni correction; P=5.6×10−3 (calculated as 0.05/9). P value in bold is still maintained significance after Bonferroni correction.