Table 3. Summary of the regression analyses for four herpes disease phenotypes (N=388 HSV1-seropositive subjects).

Factor	Intercept	Sex	Ethnicity	Age	Hap 2	Hap 3	Hap 4	Hap 5/6
Response variable=affection status
Effect size	0.955	−0.614	−0.786	0.013	−0.203	−0.531	−0.194	−0.616
Conventional s.e.	0.312	0.167	0.232	0.007	0.234	0.280	0.264	0.318
Conventional P value	0.002	<0.001	0.001	0.059	0.385	0.058	0.463	0.053
Bootstrap s.e.	0.413	0.242	0.340	0.010	0.228	0.271	0.243	0.319
Bootstrap P value	0.019	0.010	0.021	0.164	0.362	0.050	0.417	0.056
Response variable=annual outbreaks
Effect size	5.277	−1.598	−1.827	−0.026	0.380	−1.110	0.758	−1.014
Conventional s.e.	0.708	0.401	0.591	0.015	0.525	0.664	0.598	0.753
Conventional P value	<0.001	<0.001	0.002	0.086	0.470	0.095	0.205	0.178
Bootstrap s.e.	0.979	0.490	0.626	0.022	0.501	0.408	0.692	0.449
Bootstrap P value	<0.001	0.001	0.006	0.200	0.451	0.006	0.263	0.025
Response variable=lifetime outbreaks
Effect size	31.847	−37.739	−15.763	1.890	5.211	−28.389	0.768	−25.107
Conventional s.e.	15.299	8.663	12.780	0.330	11.343	14.354	12.913	16.267
Conventional P value	0.038	<0.001	0.218	<0.001	0.646	0.048	0.953	0.123
Bootstrap s.e.	19.811	10.654	23.411	0.496	11.410	11.353	13.137	12.765
Bootstrap P value	0.105	0.001	0.471	<0.001	0.654	0.012	0.957	0.050
Response variable=perceived severity
Effect size	1.738	−0.465	−0.396	0.001	−0.208	−0.344	−0.110	−0.238
Conventional s.e.	0.143	0.081	0.119	0.003	0.106	0.134	0.121	0.152
Conventional P value	<0.001	<0.001	0.001	0.797	0.050	0.010	0.361	0.118
Bootstrap s.e.	0.191	0.113	0.172	0.004	0.103	0.130	0.112	0.163
Bootstrap P value	<0.001	<0.001	0.025	0.847	0.047	0.008	0.330	0.150

The regression analysis was also performed on the discrete variable ‘affection status’ and the continuous variables ‘annual outbreaks’, ‘lifetime outbreaks’, and ‘perceived severity’. Significant values are in bold.

Abbreviation: Hap, haplotype.