Table 1. Japanese CM-SJS/TEN with SOC patients.
|
a. Association with PTGER3 SNPs | |||||||
|---|---|---|---|---|---|---|---|
| rs number of SNP |
Frequency of genotypes (%)
Allele 1: major allele
Allele 2: minor allele |
Allele 1 versus allele 2 | Genotype 11 versus 12+22 | Genotype 11+12 versus 22 | |||
| Genotypes | Cases | Controls | P valuea Corrected Pb OR (95% CI) | P valuea Corrected Pb OR (95% CI) | P valuea Corrected Pb OR (95% CI) | ||
| rs7555865 | 11 | C/C | 56/132 (42.4) | 105/219 (47.9) | 0.106 | 0.315 | 0.0772 |
| 12 | C/T | 55/132 (41.7) | 93/219 (42.5) | ||||
| 22 | T/T | 21/132 (15.9) | 21/219 (9.59) | ||||
| rs17131450 | 11 | C/C | 97/132 (73.5) | 194/221 (87.8) | 1.22×10−4 | 6.36×10−4 | 0.0190 |
| 12 | C/T | 30/132 (22.7) | 26/221 (11.8) | 2.20×10−3 | 0.0114 | 0.342 | |
| 22 | T/T | 5/132 (3.79) | 1/221 (0.452) | 0.379 (0.228–0.630) | 0.386 (0.221–0.674) | 0.115 (0.0133–0.999) | |
| rs5702 | 11 | C/C | 87/131 (66.4) | 109/221 (49.3) | 0.0228 | 1.81×10−3 | 0.628 |
| 12 | C/T | 32/131 (24.4) | 95/221 (43.0) | 0.410 | 0.0325 | ||
| 22 | T/T | 12/131 (9.16) | 17/221 (7.69) | 1.52 (1.06–2.17) | 2.03 (1.30–3.18) | ||
| rs1325949 | 11 | A/A | 91/132 (68.9) | 105/221 (47.5) | 1.94×10−3 | 8.86×10−5 | 0.950 |
| 12 | A/G | 30/132 (22.7) | 98/221 (44.3) | 0.0349 | 1.59×10−3 | ||
| 22 | G/G | 11/132 (8.33) | 18/221 (8.14) | 1.77 (1.23–2.55) | 2.45 (1.56–3.86) | ||
| rs2421805 | 11 | T/T | 44/130 (33.8) | 104/216 (48.1) | 1.93×10−3 | 9.21×10−3 | 0.0108 |
| 12 | T/G | 65/130 (50.0) | 96/216 (44.4) | 0.0348 | 0.166 | 0.194 | |
| 22 | G/G | 21/130 (16.2) | 16/216 (7.41) | 0.602 (0.436–0.831) | 0.551 (0.351–0.865) | 0.415 (0.208–0.829) | |
| rs7543182 | 11 | G/G | 92/132 (69.7) | 112/221 (50.7) | 9.29×10−3 | 4.64×10−4 | 0.591 |
| 12 | G/T | 29/132 (22.0) | 94/221 (42.5) | 0.167 | 8.36×10−3 | ||
| 22 | T/T | 11/132 (8.33) | 15/221 (6.79) | 1.63 (1.13–2.36) | 2.24 (1.42–3.53) | ||
| rs.7555874 | 11 | G/G | 91/132 (68.9) | 112/221 (50.7) | 0.0130 | 7.85×10−4 | 0.591 |
| 12 | G/A | 30/132 (22.7) | 94/221 (42.5) | 0.234 | 0.0141 | ||
| 22 | A/A | 11/132 (8.33) | 15/221 (6.79) | 1.59 (1.10–2.30) | 2.16 (1.37–3.40) | ||
| rs4147115 | 11 | A/A | 45/128 (35.2) | 54/212 (25.5) | 0.0603 | 0.0569 | 0.291 |
| 12 | A/T | 54/128 (42.2) | 99/212 (46.7) | ||||
| 22 | T/T | 29/128 (22.7) | 59/212 (27.8) | ||||
| rs4650093 | 11 | C/C | 84/132 (63.6) | 113/220 (51.4) | 0.129 | 0.0247 | 0.486 |
| 12 | C/T | 37/132 (28.0) | 93/220 (42.3) | 0.445 | |||
| 22 | T/T | 11/132 (8.33) | 14/220 (6.36) | 1.66 (1.06–2.58) | |||
| rs17131478 | 11 | G/G | 86/131 (65.6) | 135/219 (61.6) | 0.420 | 0.452 | 0.613 |
| 12 | G/T | 41/131 (31.3) | 75/219 (34.2) | ||||
| 22 | T/T | 4/131 (3.05) | 9/219 (4.11) | ||||
| rs17131479 | 11 | C/C | 87/132 (65.9) | 135/217 (62.2) | 0.485 | 0.486 | 0.744 |
| 12 | C/G | 41/132 (31.1) | 74/217 (34.1) | ||||
| 22 | G/G | 4/132 (3.03) | 8/217 (3.69) | ||||
| rs7521005 | 11 | A/A | 84/132 (63.6) | 114/221 (51.6) | 0.138 | 0.0273 | 0.479 |
| 12 | A/G | 37/132 (28.0) | 93/221 (42.1) | 0.491 | |||
| 22 | G/G | 11/132 (8.33) | 14/221 (6.33) | 1.64 (1.06–2.56) | |||
| rs7541092 | 11 | G/G | 86/131 (65.6) | 136/218 (62.4) | 0.488 | 0.540 | 0.608 |
| 12 | G/A | 41/131 (31.3) | 73/218 (33.5) | ||||
| 22 | A/A | 4/131 (3.05) | 9/218 (4.13) | ||||
| rs1327464 | 11 | G/G | 83/131 (63.4) | 194/219 (88.6) | 7.92×10−10 | 1.90×10−8 | 1.23×10−3 |
| 12 | G/A | 40/131 (30.5) | 24/219 (11.0) | 1.43×10−8 | 3.41×10−7 | 0.0221 | |
| 22 | A/A | 8/131 (6.11) | 1/219 (0.457) | 0.232 (0.142–0.381) | 0.223 (0.129–0.385) | 0.0705 (0.00872–0.571) | |
| rs1409161 | 11 | G/G | 57/132 (43.2) | 68/221 (30.8) | 0.0988 | 0.0183 | 0.958 |
| 12 | G/A | 52/132 (39.4) | 114/221 (51.6) | 0.329 | |||
| 22 | A/A | 23/132 (17.4) | 39/221 (17.6) | 1.71 (1.09–2.67) | |||
| rs34885906 | 11 | T/T | 120/132 (90.9) | 189/221 (85.5) | 0.152 | 0.138 | — |
| 12 | T/C | 12/132 (9.09) | 32/221 (14.5) | ||||
| 22 | C/C | 0/132 (0.00) | 0/221 (0.00) | ||||
| rs2817864 | 11 | T/T | 77/132 (58.3) | 118/221 (53.4) | 0.146 | 0.367 | 0.0352 |
| 12 | T/G | 53/132 (40.2) | 89/221 (40.3) | — | — | 0.634 | |
| 22 | G/G | 2/132 (1.52) | 14/221 (6.33) | — | — | 4.40 (0.983–19.7) | |
| rs1409981 | 11 | G/G | 37/131 (28.2) | 60/218 (27.5) | 0.874 | 0.884 | 0.664 |
| 12 | G/A | 65/131 (49.6) | 114/218 (52.3) | ||||
| 22 | A/A | 29/131 (22.1) | 44/218 (20.2) | ||||
|
b. Interaction between HLA-A*02:06 and PTGER3 rs1327464 GA/AA | |||||
|---|---|---|---|---|---|
| HLA-A*02:06 | rs1327464 GA or AA | CM-SJS/TEN with SOC | Controls | P valuea | OR (95% CI) |
| + | + | 22/131 (16.8%) | 4/218 (1.83%) | 2.56×10−7 | 10.8 (3.63–32.1) |
| + | − | 39/131 (29.8%) | 26/218 (11.9%) | 3.38×10−5 | 3.13 (1.80–5.45) |
| − | + | 26/131 (19.9%) | 21/218 (9.63%) | 6.80×10−3 | 2.32 (1.25–4.33) |
| − | − | 44/131 (33.6%) | 167/218 (76.6%) | 1.74×10−15 | 0.154 (0.0956–0.249) |
Abbreviations: CI, confidence interval; CM-SJS, cold medicine-related Stevens–Johnson syndrome; OR, odds ratio; SOC, severe ocular complication; SNP, single-nucleotide polymorphism; TEN, toxic epidermal necrolysis.
a
P value for allele or genotype frequency. Comparison was between patients and controls using the chi-square test (Pearson).
b
Corrected P: P values corrected for the multiplicity of testing by the number of comparisons (n=18).
In table 1a, bold values denote P values that are significant after correction for the multiplicity of testing by the number of comparisons. In table 1b, bold value denotes OR with additive effect.