Table 2. Korean CM-SJS/TEN with SOC patients.
|
a. Association with PTGER3 SNP | |||||||
|---|---|---|---|---|---|---|---|
| rs number of SNP |
Frequency of genotypes (%)
Allele 1: major allele
Allele 2: minor allele |
Allele 1 versus allele 2 | Genotype 11 versus 12+22 | Genotype 11+12 versus 22 | |||
| Genotypes | Cases | Controls | P valuea OR (95% CI) | P valuea OR (95% CI) | P valuea OR (95% CI) | ||
| rs1327464 | 11 | G/G | 17/30 (56.7) | 101/120 (84.2) | 0.00203 | 0.00101 | — |
| 12 | G/A | 13/30 (43.3) | 19/120 (15.8) | 0.311 (0.144–0.673) | 0.246 (0.103–0.589) | ||
| 22 | A/A | 0/30 (0.00) | 0/120 (0.00) | ||||
|
b. Interaction between HLA-A*02:06 and PTGER3 rs1327464 GA/AA | |||||
|---|---|---|---|---|---|
| HLA-A*02:06 | rs1327464 GA or AA | CM-SJS/TEN with SOC | Controls | P valuea | OR (95% CI) |
| + | + | 8/30 (26.7%) | 3/120 (2.50%) | 5.58×10−6 | 14.2 (3.49–57.7) |
| + | − | 2/30 (6.67%) | 17/120 (14.2%) | 0.269 | 0.433 (0.0943–1.99) |
| − | + | 5/30 (16.7%) | 16/120 (13.3%) | 0.638 | 1.30 (0.435–3.89) |
| − | − | 15/15 (50.0%) | 84/120 (70.0%) | 0.0386 | 0.429 (0.190–0.968) |
Abbreviations: CI, confidence interval; CM-SJS, cold medicine-related Stevens–Johnson syndrome; OR, odds ratio; SOC, severe ocular complication; SNP, single-nucleotide polymorphism; TEN, toxic epidermal necrolysis.
a
P value for allele or genotype frequency. Comparison was between patients and controls using the chi-square test (Pearson).
In table 1a, bold values denote P values that are significant after correction for the multiplicity of testing by the number of comparisons. In table 1b, bold value denotes OR with additive effect.