Table 2. Characteristics of the patients with BRCA1 and TP53 mutations.
| Family/patient# | Cancer | Age at diagnostica | Histology | Grade | U/B | ER | PgR | HER2 | Self-reported color |
Ancestry (%)b |
Mutation | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Af | Am | Eu | |||||||||||
| 4.1 | Ov/Br | 38 | -/Serous | -/II | U | — | — | — | White | 14.6 | 10.1 | 75.3 | BRCA1 3450del4 |
| 13.1 | Br | 47 | IDC | — | U | — | — | — | White | 29.2 | 9.6 | 61.2 | BRCA1 3450del4 |
| 21.1 | Br | 32 | IDC | — | U | — | — | — | White | 19.8 | 14.4 | 65.8 | BRCA1 3450del4 |
| 34.2 | Br/Ov | 39 | IDC/serous | III/II | U | neg | neg | neg | White | 27.0 | 6.5 | 66.5 | BRCA1 p.R71G |
| 80.2 | Br | 46 | Medular | X | U | neg | neg | neg | Mulatto | 50.7 | 10.5 | 38.8 | BRCA1 p.R71G |
| 97.1 | Br | 53 | Lobular invasive | I | U | pos | pos | neg | White | 17.4 | 6.3 | 76.3 | TP53 p.R337H |
| 98.2 | Br | 38 | IDC | III | U | neg | neg | neg | Mulatto | 21.8 | 11.8 | 66.5 | BRCA1 3450del4 |
| 103.1 | Br | 52 | IDC | II | U | neg | neg | neg | Mulatto | 17.5 | 10.1 | 72.4 | BRCA1 p.R71G |
| 105.1 | Br | 39 | IDC | III | U | neg | pos | neg | Mulatto | 29.3 | 11.2 | 59.5 | BRCA1 p.R71G |
| 106.1 | Br | 46 | IDC | III | U | neg | neg | neg | Black | 25.7 | 10.3 | 64.0 | BRCA1 p.R71G |
Abbreviations: Af, African; Am, Amerindian; B, bilateral; Br, breast cancer; ER, estrogen receptor; Eu, European; HER2, human epidermal growth factor receptor; IDC, invasive ductal carcinoma; Ov, ovarian cancer; PgR, progesterone receptor; U, unilateral; -, data not available.
a
Age at diagnostic of the first cancer.
b
Estimated genetic ancestry.