Table 1. Summary of variations in the APC gene detected by NGS.

Type	Mutation: protein alteration	dbSNP ID a	Ref b	Obs c
synonymous SNV	c.T5268G: p.S1756S	rs866006	T	G
synonymous SNV	c.G5880A: p.P1960P	rs465899	G	A
synonymous SNV	c.G5034A: p.G1678G	rs42427	G	A
synonymous SNV	c.G4479A: p.T1493T	rs41115	G	A
synonymous SNV	c.G1635A: p.A545A	rs351771	G	A
nonsynonymous SNV	c.T5465A: p.V1822D	rs459552	T	A
deletion	c.7932_7935del: p.Y2645KfsX14	—	TTAT	—

Abbreviations: APC, adenomatous polyposis coli; NGS, next-generation sequencing; dbSNP, database for single nucleotide polymorphism; SNV, single nucleotide variant.

^aThe number registered in dbSNP human Build 142 at http://www.ncbi.nlm.nih.gov/snp/.

^bReference sequence in human genome sequence (GRCh38).

^cObserved sequence in this study.