Table 1. SNPs associated with serum ALP levels.

SNP ID	Chromosome	Positiona	Gene	Location	Minor/major allele	Minor allele frequency	P valueb
rs550057	9	136146597	ABO	intron	T/C	0.274	2.15×10−91
rs532436	9	136149830	ABO	intron	A/G	0.275	6.43×10−91
rs507666	9	136149399	ABO	intron	A/G	0.275	6.43×10−91
rs579459	9	136154168	ABO|SURF6	intergenic	C/T	0.275	7.12×10−91
rs7849280	9	136126636	LCN1L1|ABO	intergenic	G/A	0.251	1.93×10−71
rs7025839	9	136124190	LCN1L1|ABO	intergenic	A/G	0.248	1.23×10−69
rs657152	9	136139265	ABO	intron	T/G	0.431	8.19×10−68
rs687289	9	136137106	ABO	intron	T/C	0.445	3.62×10−62
rs186775362	9	136149096	ABO	intron	C/A	0.442	2.95×10−59
rs529565	9	136149500	ABO	intron	C/T	0.442	3.97×10−59
rs9411475	9	136127268	LCN1L1|ABO	intergenic	C/T	0.298	5.65×10−56
rs9919007	9	136119527	LCN1L1|ABO	intergenic	T/C	0.399	4.89×10−53
rs9411468	9	136119888	LCN1L1|ABO	intergenic	A/G	0.398	1.41×10−52
rs2071699	19	49254504	FUT1	coding	T/C	0.382	1.99×10−08

Abbreviations: ALP, alkaline phosphatase; BMI, body mass index; PCA, priciple component analysis; SNP, single-nucleotide polymorphism.

SNPs with a P value <1×10⁻⁵⁰ on chromosome 9 and those with a P value <the genome-wide significance level of 5×10⁻⁸ on chromosomes other than chromosome 9 are shown.

^aGenome position is based on NCBI build 37.1.

^bThe P values in the GWAS stage are based on linear regression analysis of the log-transformed ALP values with adjustments for age, sex, BMI and the top two eigenvectors in PCA analysis, assuming an additive model by PLINK.