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. 2016 Jan 7;3:15060. doi: 10.1038/hgv.2015.60

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Copyright © 2016 Official journal of the Japan Society of Human Genetics

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TRIM11 candidate variant p.H414Y. (a) Molecular model of the structure of TRIM11. The arrow points at the TRIM11 p.H414Y mutation. Other residues in sphere format indicate corresponding familial Mediterranean fever pathogenic mutations from TRIM20. (b) Relative activity in luciferase reporter assays testing the activity of the NF-κB promoter and the interferon signaling response element under ectopic expression of the empty vector (Vector), vector expressing wild-type TRIM11 (WT), and vector expressing p.H414Y mutated TRIM11 (H414Y). (c) Immunostaining of TRIM11 in murine intestinal sections, original magnification: left (×200), right (×400). ISRE, interferon signaling response element; NF-κB, nuclear factor of kappa light chain enhancer in B-cells.