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. 2016 Jan 6;594(3):611–623. doi: 10.1113/JP271473

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© 2015 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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A, time course of the effects of ryanodine (1 μmol l^–1). B, specimen, magnified transients to emphasise the change in diastolic [Ca²⁺]_i. C, normalised transients. D, mean data (16 cells, 11 rats) for the time course of change of (from top to bottom): amplitude (Ampl); diastolic Ca (Diast); rate constant (RC) of decay of the Ca transient. The 9 min point shows both fast and slow rate constants. The amplitude of the Ca transient and diastolic Ca were significantly decreased at 3, 6 and 9 min. The rate of decay was only significantly deceased at 9 min (slow phase of decay).