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. 2016 Jan 6;594(3):611–623. doi: 10.1113/JP271473

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© 2015 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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All data obtained in the presence of ISO (1 μmol l^–1). A, time course. B, specimen, normalised transients from points indicated in A. C, mean data (6 cells, 4 rats) for the time course of change of (from top to bottom): amplitude (Ampl); diastolic Ca (Diast); rate constant (RC) of decay of the Ca transient. D, effects of adding thapsigargin in the presence of caffeine (normalised traces). E, comparison of the effects of 1 and 2 mmol l^–1 caffeine (normalised traces). F, effects of prolonged application of ryanodine (normalised traces) showing control (ISO) and after 9 and 12 min application of ryanodine.