Table 1.
Effects of rutin on intestinal pH, total acidity, free acidity and CMDI induced by MTX in rats
| Groups | Treatment | pH (mEq/l) | Total acidity | Free acidity (mEq/l) | CMDI |
|---|---|---|---|---|---|
| Group-I | Sham control (Normal saline, 3.0 ml/kg) | 7.15 ± 0.01 | 11.02 ± 0.61 | 7.47 ± 0.61 | 0.33 ± 0.15 |
| Group-II | Toxic control (MTX, 2.5 mg/kg) | 6.32 ± 0.04a | 15.06 ± 0.80a | 11.46 ± 0.58a | 4.08 ± 0.05a |
| Group-III | Rutin (50 mg/kg) | 7.67 ± 0.03***a | 11.74 ± 0.69**
(22.05 %) |
8.45 ± 0.57***
(26.20 %) |
1.17 ± 0.41***c (58.25 %) |
| Group-IV | Rutin + MTX(50 + 2.5 mg/kg) | 7.44 ± 0.02***a | 12.68 ± 0.87***
(15.74 %) |
11.14 ± 0.60a
(2.70 %) |
1.67 ± 0.52***a
(58.32 %) |
| Group-V | Rutin (100 mg/kg) | 7.81 ± 0.01***a | 11.06 ± 0.38***
(26.57 %) |
8.70 ± 0.31***
(24.01 %) |
1.17 ± 0.52***c
(58.25 %) |
| Group-VI | Rutin + MTX (100 + 2.5 mg/kg) | 7.21 ± 0.01*** | 12.75 ± 0.85***
(15.28 %) |
10.13 ± 0.71b
(11.52 %) |
2.50 ± 0.55***a
(37.50 %) |
Each group contains six animals. Values are represented as mean ± SEM
Statistical significance compared to toxic control using one-way ANOVA followed by Bonferroni test
(*P < 0.05, **P < 0.01, and ***P < 0.001). Values in parenthesis represent percentage inhibition
Statistical significance compared to sham control using one-way ANOVA followed by Bonferroni test
c P < 0.05, b P < 0.01 and a P < 0.001 were considered statistically significant