Fig. 3.
Comparison of human NEIL1 with other Fpg/Nei DNA glycosylases. (A) Superposition of human NEIL1 (blue) with EcoNei (pink; PDB ID code 1K3W) (20) and TthFpg (green; PDB ID code 1EE8) (21). The region encompassing the zinc-finger motif is boxed. An arrow points to the location of the αF-β10 loop in Fpg. (B) Close-up of the zinc-finger motif. Shown are residues 230–262 for EcoNei, 231–266 for TthFpg, and 263–290 for human NEIL1. The asterisks indicate the position of the Cα of the conserved arginine.
