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. 2016 Mar 9;18:8. doi: 10.1186/s12575-016-0037-y

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© Yao. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — The roles of miRNAs in regulating pluripotency factors in reprogramming differentiated/somatic cells for iPSC production and in stem cell differentiation. In general, miRNAs promote cell reprogramming by enhancing expression of pluripotency factors whereas they enhance stem cell differentiation by inhibiting expression of pluripotency factors