Table 2. IC50 Values of a Series of Compounds for His-Tagged-INNPP5B (0.01 μM enzyme, 50 μM Ins(1,4,5)P3), Compared to Untagged- and His-Tagged-SHIP2 (0.1 μM enzymes, 100 μM Ins(1,3,4,5)P4).
| IC50 (μM) |
|||
|---|---|---|---|
| His-Tag-INPP5B | SHIP2 (no tag) | His-Tag-SHIP2 | |
| Bz(1,2,3)P3 | 33.5 ± 6.8 | >1000 | >1000 |
| Bz(1,2,4,5)P4 | 6.3 ± 0.8 | 69.3 ± 15.4 | 108.3 ± 20.3 |
| BiPh(2,3′,4,5′,6)P5 | 2.4 ± 0.3 | 24.8 ± 3.0 | 28.4 ± 3.8 |
| BiPh(2,2′,4,4′,5,5′)P6 | 5.4 ± 0.7 | 15.5 ± 2.5 | 19.5 ± 3.1 |
| BiPh(3,3′,4,4′,5,5′)P6 | 5.5 ± 0.5 | 8.4 ± 1.6 | 12.3 ± 3.2 |