Table 3.
List of SNPs that exceed the genome-wide significance level 5 × 10−8 for USAT and MANOVA. SNPs with m.a.f. < 5% have been screened out. The SNPs listed here are the ones left after LD screening. In a group of highly correlated SNPs (i.e., SNPs with estimated absolute pairwise correlation coefficient > 0.8 with another SNP), one SNP was kept as a representative. p values for the univariate analysis of the individual traits are also provided for these significant SNPs. SNP rs ID in bold is the one detected solely by MANOVA but not by USAT at this stringent genome-wide significance level. ω denotes the weight assigned to MANOVA statistic in the USAT approach. The abbreviations used are FG (Fasting Glucose), 2-hr GL (2-hour glucose from an oral glucose tolerance test), FI (Fasting Insulin).
| chr | SNP | m.a.f. | MANOVA | USAT | Univariate Analysis p | |||
|---|---|---|---|---|---|---|---|---|
|
|
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| p | p | ω | FG | 2-hr GL | FI | |||
|
| ||||||||
| 2 | rs1260326 | 0.41 | 3.77 × 10−15 | 4.44 × 10−15 | 1.00 | 1.24 × 10−4 | 6.26 × 10−6 | 1.24 × 10−5 |
| 2 | rs13022873 | 0.27 | 9.94 × 10−10 | 2.34 × 10−9 | 1.00 | 1.49 × 10−2 | 6.01 × 10−6 | 1.07 × 10−2 |
| 2 | rs13431652 | 0.29 | 1.85 × 10−13 | 5.48 × 10−13 | 1.00 | 2.24 × 10−12 | 9.57 × 10−1 | 2.85 × 10−1 |
| 2 | rs1402837 | 0.23 | 4.91 × 10−9 | 1.15 × 10− 8 | 1.00 | 2.78 × 10−10 | 5.18 × 10−2 | 8.07 × 10−1 |
| 2 | rs484066 | 0.36 | 2.01 × 10−12 | 2.32 × 10− 12 | 1.00 | 6.10 × 10− 12 | 8.54 × 10−1 | 4.87 × 10−1 |
| 15 | rs17271305 | 0.39 | 6.87 × 10− 9 | 1.35 × 10− 8 | 1.00 | 6.29 × 10−3 | 1.17 × 10− 5 | 2.86 × 10−1 |
| 15 | rs7172432 | 0.41 | 1.68 × 10− 8 | 5.98 × 10−8 | 1.00 | 7.98 × 10−4 | 3.52 × 10− 4 | 4.88 × 10−2 |