Table 1.

Scope of the vinyl triflate coupling partner in the enantioselective alkenylative relay Heck reaction using homoallylic alcohols.

Yields are reported as an average of two parallel experiments. Ehantioselectivity determined by SFC equipped with a chiral column. Reaction performed on 0.5 mmol scale. Absolute configuration determined to be (R) for a synthetic derivative of 4b arising from the (Z)-alkene. All others were assigned by analogy.

^aReaction performed at room temperature.