Table 2.
Unadjusted hazard ratio for CD4/CD8 ratio (per 0.1 increase) | Adjusted hazard ratio for CD4/CD8 ratio (per 0.1 increase) | |||||
---|---|---|---|---|---|---|
HR | 95% CI | P value | aHR | 95% CI | P value | |
All NCDsa (n=182 events) | 0.95 | 0.91–0.99 | 0.014 | 0.97 | 0.92–1.02 | 0.17 |
Interaction term for age and CD4/CD8 ratio | 0.35 | |||||
Cardiovascular diseaseb (n=69 events) | 0.90 | 0.84–0.97 | 0.006 | 0.92 | 0.84–1.01 | 0.096 |
Interaction term for age and CD4/CD8 ratio | 0.94 | |||||
Coronary artery disease aloneb (n=46 events) | 0.85 | 0.76–0.94 | 0.002 | 0.87 | 0.76–0.99 | 0.034 |
Interaction term for age and CD4/CD8 ratio | 0.71 | |||||
Cancerc (n=50 events) | 0.94 | 0.87–1.02 | 0.16 | 0.98 | 0.89–1.07 | 0.60 |
Interaction term for age and CD4/CD8 ratio | 1.00 | |||||
Diabetesb (n=49 events) | 1.00 | 0.94–1.07 | 0.92 | 0.95 | 0.87–1.04 | 0.31 |
Interaction term for age and CD4/CD8 ratio | 0.56 | |||||
Cirrhosisd (n=22 events) | 0.95 | 0.84–1.07 | 0.40 | 0.96 | 0.86–1.08 | 0.54 |
Interaction term for age and CD4/CD8 ratio | 0.87 |
Adjusted model for all NCDs included CD4/CD8 ratio, age (using restricted cubic splines, 3 knots), CD4 lymphocyte count, sex, HCV infection, HBV infection, history of serious NCD at baseline, history of depression at baseline, calendar year at baseline, and total ART duration.
Adjusted model for cardiovascular disease, coronary artery disease, and diabetes events included CD4/CD8 ratio, age (using restricted cubic splines, 3 knots), CD4 lymphocyte count, race, sex, and history of depression.
Adjusted model for cancer included included CD4/CD8 ratio, age (using restricted cubic splines, 3 knots), CD4 lymphocyte count, race, and sex.
Adjusted model for cirrhosis included CD4/CD8 ratio and age (using restricted cubic splines, 3 knots)
Abbreviations used:
NCD: non-communicable disease
HR: hazard ratio
aHR: adjusted hazard ratio
CI: confidence interval