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. Author manuscript; available in PMC: 2017 Mar 27.
Published in final edited form as: AIDS. 2016 Mar 27;30(6):899–908. doi: 10.1097/QAD.0000000000001005

Table 2.

Unadjusted and adjusted Cox proportional hazard models for CD4/CD8 ratio and risk of NCDs

Unadjusted hazard ratio for CD4/CD8 ratio (per 0.1 increase) Adjusted hazard ratio for CD4/CD8 ratio (per 0.1 increase)
HR 95% CI P value aHR 95% CI P value
All NCDsa (n=182 events) 0.95 0.91–0.99 0.014 0.97 0.92–1.02 0.17
 Interaction term for age and CD4/CD8 ratio 0.35
Cardiovascular diseaseb (n=69 events) 0.90 0.84–0.97 0.006 0.92 0.84–1.01 0.096
 Interaction term for age and CD4/CD8 ratio 0.94
Coronary artery disease aloneb (n=46 events) 0.85 0.76–0.94 0.002 0.87 0.76–0.99 0.034
 Interaction term for age and CD4/CD8 ratio 0.71
Cancerc (n=50 events) 0.94 0.87–1.02 0.16 0.98 0.89–1.07 0.60
 Interaction term for age and CD4/CD8 ratio 1.00
Diabetesb (n=49 events) 1.00 0.94–1.07 0.92 0.95 0.87–1.04 0.31
 Interaction term for age and CD4/CD8 ratio 0.56
Cirrhosisd (n=22 events) 0.95 0.84–1.07 0.40 0.96 0.86–1.08 0.54
 Interaction term for age and CD4/CD8 ratio 0.87
a

Adjusted model for all NCDs included CD4/CD8 ratio, age (using restricted cubic splines, 3 knots), CD4 lymphocyte count, sex, HCV infection, HBV infection, history of serious NCD at baseline, history of depression at baseline, calendar year at baseline, and total ART duration.

b

Adjusted model for cardiovascular disease, coronary artery disease, and diabetes events included CD4/CD8 ratio, age (using restricted cubic splines, 3 knots), CD4 lymphocyte count, race, sex, and history of depression.

c

Adjusted model for cancer included included CD4/CD8 ratio, age (using restricted cubic splines, 3 knots), CD4 lymphocyte count, race, and sex.

d

Adjusted model for cirrhosis included CD4/CD8 ratio and age (using restricted cubic splines, 3 knots)

Abbreviations used:

NCD: non-communicable disease

HR: hazard ratio

aHR: adjusted hazard ratio

CI: confidence interval