Table 5.
Detectable levels of immune biomarkers and the association with term and preterm preeclampsia (normotensive women are the reference).
| Preterm Preeclampsia | Term Preeclampsia | |||
|---|---|---|---|---|
| Biomarker | n(%) detectable | ** Odds ratio (95% CI) | n(%) detectable | ** Odds ratio (95% CI) |
| * RANTES | 81(93.1) | 0.6(0.3–1.6) | 298(92.3) | 0.7(0.4–1.2) |
| IL4r | 73(83.9) | 0.6(0.3–1.3) | 272(84.2) | 0.7(0.4–1.1) |
| * IL6ra | 87(100.0) | *** | 318(98.5) | 1.1(0.2–4.8) |
| * MIF2 | 59(67.8) | 0.9(0.5–1.4) | 195(60.4) | 1.2(0.9–1.7) |
| MIP | 64(73.6) | 0.7(0.4–1.2) | 274(84.8) | 1.4(0.9–2.1) |
| TNFR1 | 79(90.8) | 1.1(0.5–2.5) | 300(92.9) | 1.4(0.8–2.5) |
| TNFα | 22(25.3) | 1.2(0.7–2.2) | 83(25.7) | 1.2(0.9–1.8) |
| IL6 | 26(29.9) | 1.1(0.7–1.9) | 117(36.2) | 1.5(1.1–2.2) |
| IL4 | 39(44.8) | 0.7(0.4–1.1) | 185(57.3) | 1.1(0.8–1.5) |
| IL5 | 76(87.4) | 1.0(0.5–2.0) | 292(90.4) | 1.3(0.8–2.2) |
| IL12 | 38(43.7) | 1.0(0.6–1.6) | 162(50.2) | 1.3(0.9–1.8) |
| IL1α | 9(10.3) | 0.6(0.3–1.2) | 58(17.9) | 1.1(0.7–1.7) |
| IL1β | 78(89.7) | 0.5(0.2–1.2) | 292(90.4) | 0.6(0.3–1.0) |
| IL8 | 27(31.0) | 1.0(0.6–1.6) | 116(35.9) | 1.2(0.8–1.6) |
| IL10 | 74(85.1) | 1.0(0.5–2.0) | 268(82.9) | 0.9(0.6–1.4) |
| IFNγ | 51(58.6) | 1.3(0.8–2.1) | 180(55.7) | 1.1(0.8–1.6) |
| * IL18 | 81(93.1) | 0.7(0.3–1.7) | 278(86.1) | 1.5(0.9–2.4) |
| TGFβ | 54(62.1) | 0.9(0.6–1.5) | 232(71.8) | 1.4(1.0–2.0) |
| TNFβ | 66(75.9) | 1.3(0.7–2.3) | 260(80.5) | 1.7(1.1–2.5) |
*
Indicates that biomarker had upper limit of detection (LOD)
**
Immune markers were dichotomized by the LOD and adjusted for body mass index and smoking using logistic regression
***
Cell size too small for logistic regression