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Surfactant administration and intubation criteria in preterm infants on nCPAP PEEP ≥ 6cmH2O) (control and less invasive surfactant administration groups).
| Surfactant Administration Criteria | Intubation Criteria |
|---|---|
| FiO2>50% (SpO2 90-95%) | |
| First dose: FiO2>30% (SpO2 90-95%) Second dose: FiO2>40% (SpO2 90-95%) | Apnea episodes (>4/h or more than 1 requiring PPV) |
| Respiratory acidosis, pCO2>65 mmHg and pH<7.20 in arterial or capillary samples |
PEEP: Positive end-expiratory pressure.
