Table 3.
Postnatal respiratory management of less invasive surfactant administration and INSURE groups.
| LISA N=30 | STANDARD TREATMENT N=30 | p (95% CI) | |
|---|---|---|---|
| Gestational age (weeks), median | 28.4 | 29.1 | 0.15 |
| Age at procedure (hours), mean(SD) | 11.4(14.7) | 11(14.7) | 0.76 |
| 2 or more attempts, n(%) | 5(16.7) | - | |
| Bradycardia (>10 seg), n(%) | 3(10) | - | |
| Surfactant reflux, n(%) | 2(6.7) | - | |
| FiO2 before procedure, % | 42 | 40 | 0.58 |
| FiO2 reduction (>20%), n(%) | 22(73.3) | 26(86.6) | 0.08 |
| Second dose of surfactant, n(%) | 10(33.3) | 9(30) | 0.39 |
| Pneumothorax, n(%) | 2(6.7)* | 1(3.3) | 0.55 |
| iMV >1 hour during first 3 days, n(%) | 13(43) | 22(73) | 0.036 |
| Total iMV (hours) | 84.12 | 82.22 | 0.37 |
| PDA, n(%) | 11(36.7) | 12(40) | 0.79 |
| Death or BPD (II-III), n(%) | 8(26.6) | 9(30) | 0.61 |
| Pharmacological analgesics, n(%) | 0(0%) | 9(30%) | <0.05 |
<?ENTCHAR ast?>: previously.
LISA: less invasive surfactant administration.
BPD: bronchopulmonary dysplasia; iMV: invasive mechanical ventilation; PDA: patent ductus arteriosus; PPI: positive pressure inflations; SD: standard deviation.