Figure 3.
Validation in an independent cohort. (A) The replication of HVM sites. Total of 675 (75.33%) HVM sites (highlighted) identified in discovery cohort could be replicated in validation cohort. (B) The boxplot of co-expression partners of RMPGs and non-RMPGs in CRC and normal categories in the validation cohort. Similarly, the loss of co-expression connectivity can be observed, confirming the reliability of connectivity loss identified in the discovery cohort. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]