Table 1.
Pathways significantly overrepresented in the MeA greenyellow module*
| Ingenuity Canonical Pathways | −log(p-value) | Ratio | Genes |
|---|---|---|---|
| Glucocorticoid Receptor Signaling | 3.07 | 0.027 | MAP3K7, TGFB2, NFKBIE, GTF2H5, SOS1, ESR1, TAF5L |
| PPARα/RXRα Activation | 2.40 | 0.028 | MAP3K7, ACOX1, TGFB2, NFKBIE, SOS1 |
| Estrogen Receptor Signaling | 2.19 | 0.031 | GTF2H5, SOS1, ESR1, TAF5L |
| Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes | 1.96 | 0.038 | TGFB2, NFKBIE, SOS1 |
| Hepatic Cholestasis | 1.83 | 0.025 | MAP3K7, TGFB2, NFKBIE, ESR1 |
| Thyroid Hormone Biosynthesis | 1.76 | 0.333 | IYD |
| PPAR Signaling | 1.76 | 0.032 | MAP3K7, NFKBIE, SOS1 |
| IL-17A Signaling in Fibroblasts | 1.75 | 0.057 | MAP3K7, NFKBIE |
| tRNA Charging | 1.66 | 0.051 | AARS2, IARS2 |
| Role of PKR in Interferon Induction and Antiviral Response | 1.64 | 0.050 | MAP3K7, NFKBIE |
| Geranylgeranyldiphosphate Biosynthesis | 1.64 | 0.250 | GGPS1 |
| Trans, trans-farnesyl Diphosphate Biosynthesis | 1.54 | 0.200 | GGPS1 |
| IL-6 Signaling | 1.52 | 0.026 | MAP3K7, NFKBIE, SOS1 |
| PKCθ Signaling in T Lymphocytes | 1.50 | 0.025 | MAP3K7, NFKBIE, SOS1 |
| Assembly of RNA Polymerase II Complex | 1.46 | 0.040 | GTF2H5, TAF5L |
| PI3K/AKT Signaling | 1.45 | 0.024 | ITGA2, NFKBIE, SOS1 |
| CD27 Signaling in Lymphocytes | 1.43 | 0.039 | MAP3K7, NFKBIE |
*
IPA identified 24 pathways significantly enriched in the MeA greenyellow module. Only those pathways that also contain well-connected genes are shown.
Ratio: Number of pathway genes in the greenyellow module divided by the total number of genes in the pathway.