Table 2.
Pathways significantly overrepresented in the HYP black module*
| Ingenuity Canonical Pathways | −log(p-value) | Ratio | Genes |
|---|---|---|---|
| RAR Activation | 2.77 | 0.057 | PRKCD, PNRC1, AKT3, MAP3K5, NT5C1B, SMAD6, TGFB2, PRKCI, GTF2H5, ERCC3 |
| RANK Signaling in Osteoclasts | 2.23 | 0.068 | MAP3K7, AKT3, MAP3K5, NFKBIE, MAP3K4, NFATC1 |
| Gαq Signaling | 2.21 | 0.054 | PRKCD, AKT3, PLCB4, HTR2C, PRKCI, NFKBIE, NFATC1, FNBP1 |
| Type II Diabetes Mellitus Signaling | 2.21 | 0.060 | MAP3K7, PRKCD, AKT3, MAP3K5, SOCS5, PRKCI, NFKBIE |
| Superpathway of D-myo-inositol (1,4,5)-trisphosphate Metabolism | 2.02 | 0.125 | IMPA2, ITPKA, BPNT1 |
| LPS-stimulated MAPK Signaling | 1.94 | 0.069 | MAP3K7, PRKCD, MAP3K5, PRKCI, NFKBIE |
| HGF Signaling | 1.87 | 0.057 | MAP3K7, PRKCD, AKT3, MAP3K5, PRKCI, MAP3K4 |
| VDR/RXR Activation | 1.83 | 0.064 | SERPINB1, PRKCD, TGFB2, PRKCI, HES1 |
| CD27 Signaling in Lymphocytes | 1.81 | 0.077 | MAP3K7, MAP3K5, NFKBIE, MAP3K4 |
| Methylthiopropionate Biosynthesis | 1.73 | 1 | ADI1 |
| Production of Nitric Oxide and Reactive Oxygen Species in Macrophages | 1.72 | 0.044 | MAP3K7, PRKCD, AKT3, MAP3K5, PRKCI, NFKBIE, MAP3K4, FNBP1 |
| G-Protein Coupled Receptor Signaling | 1.67 | 0.039 | AKT3, MC3R, PLCB4, CNR1, HTR1E,HTR2C, FSHR, ADRA2C, MC5R, NFKBIE |
| PKCθ Signaling in T Lymphocytes | 1.65 | 0.051 | GRAP2, MAP3K7, MAP3K5, NFKBIE, MAP3K4, NFATC1 |
| Hepatic Cholestasis | 1.50 | 0.043 | MAP3K7, PRKCD, TGFB2, PRKCI, HNF4A, NFKBIE, MAP3K4 |
| PI3K Signaling in B Lymphocytes | 1.50 | 0.047 | AKT3, PLCB4, PRKCI, NFKBIE, NFATC1, DAPP1 |
| GNRH Signaling | 1.48 | 0.047 | MAP3K7, PRKCD, MAP3K5, PLCB4, PRKCI, MAP3K4 |
| Mismatch Repair in Eukaryotes | 1.46 | 0.125 | RPA1, MSH2 |
| Erythropoietin Signaling | 1.45 | 0.060 | PRKCD, AKT3, PRKCI, NFKBIE |
| Superpathway of Geranylgeranyldiphosphate Biosynthesis I (via Mevalonate) | 1.41 | 0.118 | ACAT2, GGPS1 |
| NF-κB Signaling | 1.37 | 0.041 | MAP3K7, AKT3, NTRK2, NFKBIE, TBK1, IGF2R, FGFRL1 |
| D-myo-inositol (1,4,5)-trisphosphate Degradation | 1.37 | 0.111 | IMPA2, BPNT1 |
| B Cell Receptor Signaling | 1.34 | 0.040 | MAP3K7, AKT3, MAP3K5, NFKBIE, MAP3K4, NFATC1, DAPP1 |
| NF-κB Activation by Viruses | 1.33 | 0.055 | PRKCD, AKT3, PRKCI, NFKBIE |
| STAT3 Pathway | 1.33 | 0.055 | SOCS5, NTRK2, IGF2R, FGFRL1 |
| Role of NFAT in Cardiac Hypertrophy | 1.31 | 0.039 | MAP3K7, PRKCD, AKT3, PLCB4, SLC8A1, TGFB2, PRKCI |
| NGF Signaling | 1.31 | 0.047 | MAP3K7, PRKCD, AKT3, MAP3K5, MAP3K4 |
*
IPA identified 42 pathways significantly enriched in the HYP black module. Only those pathways that also contain well-connected genes are shown. Ratio: Number of pathway genes in the black module divided by the total number of genes in the pathway.