Fig. 2.

NF-κB and TNF gene regulation. a Putative NF-κB and NF-κB-like sites in the human and murine TNF promoters, along with the positions of SNPs in the human TNF promoter. b Stimulus-dependent association of NF-κB proteins (in at least one condition or time point studied) with the TNF promoter in ChIP assays. c Impact of deletions of NF-κB proteins in mice upon TNF gene transcription (asterisk denotes studies and cell types where only protein expression was assayed) in response to various stimuli). TEPM = Thioglycollate-elicited peritoneal macrophages; FLDM = fetal liver-derived macrophages; BMDM = bone marrow-derived macrophages; BMDC = bone marrow-derived dendritic cells; MEF = murine embryonic fibroblasts.