Table 1. Demographics and Baseline Characteristics.
| Incident EAC† | EAC Mortality | All-Cause Mortality | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| All Subjects (n = 4982) | Incident EAC (n = 100) | No EAC (n = 4598) | p-value | EAC Death (n = 9) | No EAC Death (n = 4973) | p-value | Death (n = 157) | No Death (n = 4825) | p-value | |
| Age, years (mean ± SD) | 62 ± 11 | 66 ± 10 | 61 ± 11 | <0.0001 | 74 ± 12 | 62 ± 11 | 0.004 | 72 ± 9 | 61 ± 11 | <0.0001 |
| White Race, n (%) | 4634 (95) | 95 (99) | 4264 (95) | 0.07 | 9 (100) | 4625 (95) | 0.50 | 149 (96) | 4485 (95) | 0.55 |
| Male Gender, n (%) | 3677 (74) | 82 (82) | 3349 (73) | 0.04 | 6 (67) | 3671 (74) | 0.63 | 122 (78) | 3555 (74) | 0.26 |
| Esophagectomy, n (%) | 17 (0.3) | 0 (0) | 0 (0) | -- | 0 (0) | 17 (0.3) | 0.86 | 0 (0) | 17 (0.4) | 0.46 |
| Fundoplication, n (%) | 271 (5) | 3 (3) | 260 (6) | 0.25 | 0 (0) | 271 (5) | 0.47 | 5 (3) | 266 (6) | 0.21 |
| Gastric Bypass, n (%) | 20 (0.4) | 3 (3) | 17 (0.4) | <0.0001 | 0 (0) | 20 (0.4) | 0.85 | 0 (0) | 20 (0.4) | 0.42 |
| BE length, cm (mean ± SD) | 4.1 ± 3.3 | 7.0 ± 3.8 | 4.0 ± 3.2 | <0.0001 | 5.3 ± 4.7 | 4.1 ± 3.3 | 0.53 | 4.7 ± 3.5 | 4.1 ± 3.3 | 0.01 |
| Stricture, n (%) | 187 (4) | 4 (4) | 159 (3) | 0.94 | 1 (11) | 186 (4) | 0.38 | 9 (6) | 178 (4) | 0.57 |
| Baseline Pathology | <0.0001 | <0.0001 | <0.0001 | |||||||
| NDBE, n (%) | 2346 (47) | 3 (3) | 2341 (51) | 0 (0) | 2346 (47) | 36 (23) | 2310 (48) | |||
| IND, n (%) | 368 (7) | 2 (2) | 363 (8) | 0 (0) | 368 (7) | 10 (6) | 358 (7) | |||
| LGD, n (%) | 1020 (20) | 12 (12) | 1003 (22) | 0 (0) | 1020 (21) | 26 (17) | 994 (21) | |||
| HGD, n (%) | 990 (20) | 83 (83) | 891 (19) | 6 (67) | 984 (20) | 60 (38) | 930 (19) | |||
| Intramucosal EAC, n (%) | 195 (4) | -- | -- | 3 (33) | 192 (4) | 11 (7) | 184 (4) | |||
| Invasive EAC, n (%) | 63 (1) | -- | -- | 0 (0) | 63 (1) | 14 (9) | 49 (1) | |||
†
This excludes 22 patients who died before undergoing a biopsy (3 with baseline intramucosal and 1 with baseline invasive EAC), 192 patients with baseline intramucosal EAC (4 with esophagectomy), 62 with baseline invasive EAC (5 with esophagectomy), and 8 who did not have EAC but had previously undergone esophagectomy.