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. 2004 Jun 30;101(28):10446–10451. doi: 10.1073/pnas.0403886101

Fig. 8.

Fig. 8.

Oxidative photosensitivity of mouse embryo fibroblasts to retinaldehyde. Correlation between basal levels of GSH and specific activities of NQO1 in mouse embryonic fibroblasts derived from WT mice as well as those in which keap1 (K0), nrf2 (N0), or both keap1 and nrf2 (K0N0) genes were disrupted. Mouse embryo fibroblasts were grown for 24 h and then treated with 3.2, 6.3, 12.5, and 25 μM retinaldehyde for 2 h in the dark; exposed in PBS to UVA for 20 min; and grown in serum-free medium for 18 h. Fractional survival is compared with cells treated identically without retinaldehyde.