Effects of i.c.v. injection of K17F on systemic AVP release, diuresis, natriuresis, and kaliuresis in conscious lactating mice. (A) Systemic AVP release was estimated by measuring plasma AVP levels by RIA after the i.c.v. injection of saline or K17F (0.93 nmol = 2 μg) in lactating mice. (B–D) Diuresis (B), urinary concentrations of Na+ and K+ (C), and Na+ and K+ excretion rates (UNaV and UKV) (D) were measured for 3 h after the i.c.v. injection of saline or K17F (2 μg). Mean ± SEM, n = 5 in each group. *, P < 0.05 vs. control; ns, no significant difference vs. control animals.