Figure 2.

Neonatal head modeling. (a) Anatomical MR images (T₁-weighted and T₂-weighted) obtained for each individual infant were used to create a subject-specific head model. (b) The MR images were first segmented into 4 tissue types, namely, gray matter (GM), white matter (WM), CSF, and extracerebral tissue (scalp and skull). (c) A FEM was created using the Nirview modeling software and then optical properties were assigned to each node according to the tissue type determined by the segmentation. (d) The optode grid was placed over the head model based on the fiducial points measured during the DOT scanning session. (e) A subject-specific sensitivity matrix was calculated using the NIRFAST light modeling software.