Table 5.
Principal cells |
PV-positive cells |
SST-positive cells |
||||
---|---|---|---|---|---|---|
WT (N = 27 cells) | Scn1a−/+ (N = 27 cells) | WT (N = 21 cells) | Scn1a−/+ (N = 28 cells) | WT (N = 25 cells) | Scn1a−/+ (N = 28 cells) | |
Rin (MΩ) | 103 ± 9 | 107 ± 9 | 109 ± 8 | 86 ± 5* | 208 ± 16 | 195 ± 14 |
AP amplitude (mV) | 84 ± 2 | 85 ± 1 | 66 ± 2 | 63 ± 2 | 72 ± 2 | 71 ± 2 |
AP duration (ms) | 1.04 ± 0.05 | 1.09 ± 0.04 | 0.36 ± 0.01 | 0.39 ± 0.01 | 0.65 ± 0.02 | 0.79 ± 0.04** |
AP rise time (ms) | 0.59 ± 0.03 | 0.59 ± 0.02 | 0.37 ± 0.01 | 0.40 ± 0.01* | 0.56 ± 0.02 | 0.63 ± 0.02** |
AP threshold (mV) | −42.6 ± 0.7 | −42.0 ± 0.8 | −41.7 ± 1.1 | −42.4 ± 0.9 | −42.1 ± 0.8 | −42.5 ± 0.7 |
Note: Statistical significance was evaluated with unpaired Student's t-test. *P < 0.05; **P < 0.01.