Table 2.
Average pharmacokinetic parameters after intravenous administration of amsacrine analog solution and amsacrine analog-loaded SLN to mice with a dose of 8.4 mg/kg for 4 hours
| Parameters | Amsacrine analog solution | Amsacrine analog-loaded SLN |
|---|---|---|
| t1/2α (hour) | 0.1955±0.002 | 0.3469±0.007 |
| t1/2β (hour) | 1.4375±0.067 | 0.8026±0.087 |
| Cl (L/h/kg) | 20.3287±1.254 | 44.0903±3.501 |
| Vdss (L/kg) | 23.1743±1.563 | 34.0650±4.184 |
| AUC0→∞ (h·μg/mL) | 0.4132±0.003 | 0.1905±0.004 |
| MRT (hour) | 1.1400±0.006 | 0.7726±0.009 |
Note: Each value represents mean ± SD (n=6).
Abbreviations: SLN, solid lipid nanoparticle; t1/2α, half-life of the distribution phase; t1/2β, half-life of the elimination phase; Cl, clearance; Vdss, steady-state volume of distribution; AUC, area under tissue concentration–time curve; MRT, mean residence; SD, standard deviation.