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. 2016 Mar 10;12(3):e1005916. doi: 10.1371/journal.pgen.1005916

Fig 1. Bacterial artificial chromosome (BAC) spanning the intact Cdkn1c locus in mice models minimal microduplication reported in Silver Russell Syndrome.

Fig 1

(A) Genomic map of human 11p15 imprinted region. Line below indicates extent of minimal region duplicated in SRS. (B) Genomic map of mouse distal chromosome 7 imprinted region. Below is the map of the 85 kb BAC transgene (BAC144D14). Inset: Image of WT and BACx1 pups carrying one copy of the BACx1 examined on a mixed 129/BL6 genetic background on postnatal day (P) 2. (C) Weights of WT and BAC transgenic pups at birth (P0) after breeding onto BL6 genetic background for >12 generations. (D) Brain weight to body weight ratio. (E) Blood glucose levels (mmol/l). NS = not significant. Data expressed as mean ± SEM, t test. Numbers given in S1 Fig.