Fig 3. The long-term epidemiological effects of integrating clinical interventions with transgenic population reduction.

(A) The prevalence (fraction of hosts infectious) at equilibrium after combined vaccination and transgenic population reduction relative to prevalence before the interventions begin, and (B) the corresponding effective type reproductive number at the equilibrium in (A) in the absence of an antimicrobial medication. (C-D) describe analogous results assuming vaccination and transgenic population reduction are combined with an antimicrobial medication strategy that removes infectious hosts at the same rate as the background recovery rate, while (E-F) describe the results when an antimicrobial medication strategy that removes infectious hosts at twice the background recovery rate is used. Panels (A-B) illustrate how absent transgenic manipulation long-term pathogen elimination is only possible in our model if the fraction of hosts vaccinated exceeds approximately 0.78, which corresponds to roughly 1 − 1/T_R (e.g., [85]) for the parameter values in Table 1.