Fig 4. Epidemiological effects of integrating clinical interventions with transgenic manipulation over a 10-year time horizon.

All panels on the left-hand side depict results for transgenic vector manipulation that aims at population replacement, while panels on the right-hand side depict results for transgenic vector manipulation aiming at population reduction. All panels describe the total number of cases (cumulative incidence) over the time horizon relative to the same quantity in the absence of any public health management programs ($\widehat{q_P}\left(T_H\right)$; see Eq (5).) Panels (A-B) show the effect on $\widehat{q_P}\left(T_H\right)$ when no antimicrobial medication is administered in addition to a vaccination program. In (C-D), the medication-induced recovery rate is 1/30 per day, which is 20% of the natural recovery rate.