. 2016 Mar 10;12(3):e1004695. doi: 10.1371/journal.pcbi.1004695

Table 1. Model parameters and their numerical values.

Parameter	Interpretation	Units	Default values	Reference/notes
b	Influx of (susceptible) hosts	hosts ⋅ day⁻¹	45.7	Results in an equlibrium host density of 10⁶ without the pathogen
ψ, ϕ	Transmission constants governing acquisition of pathogen from infectious vectors to susceptible hosts (ψ), as well as the acquisition of pathogen from infectious hosts to susceptible vectors (ϕ) in the absence of genetic vector manipulation	day ⁻¹	0.2	Inferred from type reproductive number^a
d	Host background per-capita mortality rate	day⁻¹	$\frac{1}{21900}$	[51, 52]
a	Pathogen induced per-capita host mortality rate	day⁻¹	0.008549	Based on [67], which reports of a 5% host mortality rate from dengue
g	Natural infectious host recovery rate	day⁻¹	$\frac{1}{6}$	[51]
r	Intrinsic per-capita vector growth rate	day⁻¹	0.835	Midpoint of range in [99]
k	Density-dependent effects on recruitment	(vectors ⋅ day)⁻¹	3.675×10⁻⁷	Based on an assumption of approximately 2 vectors per host
μ	Vector per-capita mortality rate	day⁻¹	$\frac{1}{10}$	[44] and [96]
β	Parameter governing average vector competence immediately following the onset of the release of transgenic mosquitoes	−	−10	Calibrated so that at t = 0, G(t) = 0.99995 (i.e., very close to 1).
α	Parameter governing the decline in vector competence	day⁻¹	Varied	−
ρ	The number of transgenic males carrying a dominant lethal construct released	−	Varied	−
ϵ	Fraction of new hosts vaccinated	−	Varied	−
δ	Medication-induced recovery rate	day⁻¹	Varied	−

Parameters, their interpretations, units, and default values used in the numerical analysis. Unless stated otherwise, the default values represent the midpoint of the ranges reported in the relevant sources.

^a For dengue, the number of secondary host infections arising from a single host infection (the type reproductive number) in the literature has typically been reported to range from less than 1 to greater than 10 (e.g., [51] and [40]). We present results in the main text for a type reproductive number of approximately 4.56.