Fig 3. A₃, A_2A or A₁ adenosine receptors regulate expression of the main pro-angiogenic factors in B16F10 melanoma.

Protein expression was analyzed in lysates from tumors on the 14^th day of growth in WT or CD73^-/- mice. CD73^-/- mice were treated with AOPCP and, where indicated, with specific adenosine receptor agonist, IB-MECA (agonist for A₃AR), CGS-2168 (A_2AAR) or CCPA (A₁AR). For separate control of agonist solvent, WT mice were treated with DMSO. Semi-quantitative antibody microarrays were used to obtain protein expression profile presented as the fold change between groups calculated from the mean values for each protein separately, assuming that the average expression of the protein in all three control groups is equal to 1. *P<0.05 vs. WT, ^#P<0.05 vs. WT + DMSO, ^$P<0.05 vs. CD73^-/- + AOPCP (other statistical differences are not shown).