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. 2016 Mar 10;11(3):e0149441. doi: 10.1371/journal.pone.0149441

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© 2016 Patel et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — Genotype—phenotype correlation of exon 1 +49A/G and 3’ UTR CT60A/G polymorphisms of flCTLA4 and sCTLA4 in controls and autoimmune hypothyroidism patients: (A) Relative mRNA expression of flCTLA4 with respect to +49A/G genotypes in 45 patients and 60 controls. None of the three genotypes AA (p = 0.0667), AG (p = 0.0141) and GG (p = 0.0007) in patients showed significant difference for flCTLA4 expression as compared to controls a suggested by Mean ΔCp. [NS = non-significant] (B) Relative mRNA expression of sCTLA4 with respect to +49A/G genotypes in 45 patients and 60 controls. None of the three genotypes AA (p = 0.6260), AG (p = 0.0358) and GG (p = 0.0102) in patients showed significant difference for flCTLA4 expression as compared to controls a suggested by Mean ΔCp. [NS = non-significant] (C) Relative mRNA expression of flCTLA4 with respect to CT60A/G genotypes in 45 patients and 60 controls. GG genotype showed significant decrease in the levels of flCTLA4 mRNA (p<0.0001) in patients as compared to AA and AG genotype (p = 0.5817 & p = 0.2379 respectively) as suggested by Mean ΔCp. [NS = non-significant] (D) Relative mRNA expression of sCTLA4 with respect to CT60A/G genotypes in 45 patients and 60 controls. GG genotype showed significant decrease in levels of sCTLA4 mRNA (p = 0.0001) in patients as compared to AA and AG genotype (p = 0.7099 & p = 0.7478 respectively) as suggested by Mean ΔCp. [NS = non-significant].