Table 1. Association studies for CTLA4 gene exon 1 +49A/G and 3’UTR CT60A/G polymorphisms and TG gene exon 33 polymorphism in autoimmune hypothyroidism patients.
| SNP | Genotype or allele | Patients (Frequency) n = 49 | Controls (Frequency) n = 62 | P for Association | Odds ratio (95% CI) |
|---|---|---|---|---|---|
| CTLA4 Exon1 (+49A/G) | AA | 8(0.16) | 32(0.52) | R | 1 |
| AG | 28(0.57) | 21(0.34) | 0.0004a | 5.333(2.043 to 13.92) | |
| GG | 13(0.27) | 9(0.14) | 0.0019b | 5.778(1.829 to 18.25) | |
| A | 44(0.45) | 85(0.69) | 0.0004c | ||
| G | 54(0.55) | 39(0.31) | |||
| CTLA4 (CT60A/G) 3’UTR | AA | 4(0.08) | 22(0.35) | R | 1 |
| AG | 15(0.31) | 17(0.27) | 0.0110a | 4.853(1.360 to 17.31) | |
| GG | 30(0.61) | 23(0.37) | 0.0005b | 7.174(2.169 to 23.73) | |
| A | 23(0.23) | 61(0.49) | <0.0001c | ||
| G | 75(0.77) | 63(0.51) | |||
| TG Exon33 | TT | 4(0.08) | 29(0.47) | R | 1 |
| TC | 28(0.57) | 27(0.43) | 0.0003a | 7.519(2.329 to 24.27) | |
| CC | 17(0.35) | 6(0.10) | < 0.0001b | 20.54(5.065 to 83.30) | |
| T | 36(0.37) | 85(0.69) | <0.0001c | ||
| C | 62(0.63) | 39(0.31) |
‘n’ represents number of Patients/ Controls, CI refers to Confidence Interval, R refers to Reference Group
a and b represents Patients vs. Controls (genotype) using chi-squared test with 2 × 2 contingency table for AA vs AG and AA vs GG of +49A/G and CT60, and respectively for TT vs CT and TT vs CC of TG exon33.
c represents Patients vs. Controls (allele) using chi-squared test with 2 × 2 contingency table.