Fig 1. Statistical mechanical basis of the information thermodynamic model.

(A) Analysis based on Weibull distribution. (B) Analysis based on GG distribution. Under Landauer’s principle statistical mechanical probability distributions were derived for the absolute amount of information I_R processed by the methylation machinery in a genomic region R (Eqs 12 and 14, Material and Methods). For each partition of the methylome into genomic regions, nonlinear fits were performed to estimate the scaling parameter $\widehat{\lambda }\left(l\right)$. Next, regression functions were obtained from the regression analyses $\overline{\widehat{\lambda }}\left(l\right)$ versus l, as predicted by Eq 18 (19). The estimations of the DNA persistence length ${\widehat{L}}_p$ were based on Eq 20.