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. 2016 Mar 10;11(3):e0150918. doi: 10.1371/journal.pone.0150918

Fig 5. Effect of Acetazolamide on pendrin expression, urine output and water intake in WT and NCC KO mice.

Fig 5

Fig 5a shows the expression of pendrin in WT and NCC KO mice treated with acetazolamide for 2 or 6 days (left and right panels). Fig 5b and 5c depicts the urine output (i) and water intake (ii) in WT and NCC KO mice treated with ACTZ. The increase in urine output by ACTZ in NCC KO mice correlated with a reduction in pendrin expression. Fig 5d demonstrates enhanced sodium excretion by ACTZ in NCC KO mice vs. WT animals.