Table 2. Viral pathogens detected with real time reverse transcriptase PCR in respiratory tract samples of patients admitted to the paediatric intensive care unit (PICU) with or without a severe acute respiratory tact infection (SARI) and medium care (MC) admitted patients with or without an acute respiratory tract infection (ARTI) at the Erasmus MC-Sophia over a 5-year period (2007–2012).
| Viruses | PICU-SARI patients with a single virus and no bacterial co-infection n = 44 (%) | All PICU admitted patients with a single virus n = 277 (%) | MC-ARTI patients with a single virus and no bacterial co-infection n = 40 (%) | All MC admitted patients with a single virus n = 588 (%) | p-value between PICU-SARI patients and MC-ARTI patients | p-value between all PICU and all MC patients |
|---|---|---|---|---|---|---|
| Rhinovirus | 11 (25) | 86 (31) | 12 (30) | 247 (42) | 0.6 | 0.002 |
| Respiratory syncytial virus | 13 (30) | 65 (24) | 13 (33) | 86 (15) | 0.8 | 0.002 |
| Adenovirus | 1 (2) | 27 (10) | - | 28 (5) | - | 0.007 |
| Human bocavirus | 7 (16) | 23 (8) | 2 (5) | 40 (7) | 0.2 | 0.5 |
| Influenza A virus | 4 (9) | 22 (8) | 1 (3) | 40 (7) | 0.4 | 0.6 |
| Human metapneumovirus | 1 (2) | 12 (4) | 3 (8) | 23 (4) | 0.3 | 0.9 |
| Parainfluenzavirus type 1 | 2 (5) | 10 (4) | 1 (2) | 9 (2) | ns* | 0.08 |
| Human coronavirus OC43 | 1 (2) | 10 (4) | 2 (5) | 16 (3) | 0.6 | 0.5 |
| Parainfluenzavirus type 3 | 1 (2) | 7 (3) | 5 (13) | 36 (6) | 0.1 | 0.03 |
| Parainfluenzavirus type 4 | 1 (2) | 6 (2) | 1 (3) | 13 (2) | ns | ns |
| Human coronavirus NL63 | 2 (5) | 5 (2) | - | 20 (3) | - | 0.3 |
| Influenza B virus | - | 2 (1) | - | 15 (3) | - | 0.1 |
| Parainfluenza virus type 2 | - | 1 (0.4) | - | 7 (1) | - | 0.5 |
| Human coronavirus 229E | - | 1 (0.4) | - | 8 (1) | - | 0.3 |
* ns, not significant.