Fig 6. Inhibition of the 5-HT_2A mediated, DOI-induced head-twitch response by nuciferine.

(a) Dose response curves of a 15-minute nuciferine pretreatment on the 1.0 mg/kg DOI-induced head twitch response. Solid lines indicate intraperitoneal administration of nuciferine. Dashed line indicates subcutaneous administration of nuciferine. Dose of nuciferine indicated to right of its associated data line. (b) Effect of nuciferine pretreatment time on the suppression of the DOI-induced head-twitch response. All pretreatments were administered intraperitoneally. DOI-alone condition provided as reference. Pretreatment time indicated to right of its associated data line. Data are presented as the mean number of cumulative head-twitches (y axis) at the given time point (x axis) (mean +/- s.e.m.; n = 3).