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. 2016 Mar 10;11(3):e0150602. doi: 10.1371/journal.pone.0150602

Fig 9. PPI responses to nuciferine in mouse models of hypoglutamatergia and hyperdopaminergia.

Fig 9

Nuciferine rescued PPI in the former, but not in the latter model. (a-c) Null activity (a), startle activity (b), and PPI (c) for C57BL/6J mice treated with vehicle (Veh), 5 or 10 mg/kg nuciferine (Nuc), and/or phencyclidine (PCP). (d-g) Null activity (d), startle activity (e), and PPI for wild-type (WT) (f) and dopamine transporter knockout (DAT-KO) mice (g) given Veh, 2 mg/kg clozapine (CLZ) or 2.5–10 mg/kg Nuc. N = 8–17 mice/group in the C57BL/6J experiment; *p<0.05, compared to Veh/Nuc groups; +p<0.05, compared to the Veh and PCP groups; †p<0.05, compared to all other groups. N = 9–17 mice/genotype/treatment in the DAT experiment; ^p<0.05, WT versus KO within dose; #p<0.05, dose effect within genotype; &p<0.05, overall drug effect regardless of genotype.