Table 4. Factors associated with increased lamina cribrosa curvature index (multivariate analysis).
| Variable | Multivariate analysis model 1* | Multivariate analysis model 2* | Multivariate analysis model 3* | Multivariate analysis model 4* | Multivariate analysis model 5* | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β | 95% CI | P-value | β | 95% CI | P-value | β | 95% CI | P-value | β | 95% CI | P-value | β | 95% CI | P-value | |
| Gender, male | 2.0 | –4.1, 8.1 | 0.52 | 2.6 | –5.1, 10.4 | 0.50 | 3.5 | –3.0, 10.0 | 0.29 | 3.48 | –10.0, –3.0 | 0.29 | 2.3 | –5.7, 10.3 | 0.57 |
| Untreated IOP, per 1 mmHg increase | –0.03 | –0.9, 0.9 | 0.95 | 0.6 | –0.5, 1.7 | 0.28 | 0.04 | –1.0, 1.0 | 0.94 | –0.1 | –1.0, 0.9 | 0.88 | 0.4 | –0.7, 1.6 | 0.45 |
| SE, per 1 increase | –1.3 | –2.6, –0.004 | 0.049 | –0.7 | –2.3, 0.8 | 0.35 | 0.03 | –1.4, 1.5 | 0.97 | –0.4 | –1.7, 1.0 | 0.58 | 0.1 | –1.5, 1.7 | 0.90 |
| Disc area, per 1 mm2 increase | 21.3 | 14.3, 28.2 | <0.001 | 23.9 | 15.6, 32.1 | <0.001 | |||||||||
| Rim area, per 1 mm2 increase | –27.2 | –43.3, –11.2 | 0.001 | ||||||||||||
| Vertical C/D ratio, per 0.1 increase | 63.0 | 29.3, 96.6 | <0.001 | 88.8 | 52.4, 125.2 | <0.001 | |||||||||
| Average RNFL thickness, per 1 ㎛ increase | –0.7 | –0.9, –0.4 | <0.001 | –0.2 | –0.6, 0.1 | 0.21 | |||||||||
| MD of VF, per 1 dB increase | –0.3 | –1.3, 0.8 | 0.62 | 0.7 | –0.4, 1.9 | 0.21 | |||||||||
| mLCD, per 1 ㎛ increase | 0.1 | 0.1, 0.2 | <0.001 | 0.1 | 0.1, 0.2 | <0.001 | 0.1 | 0.06, 0.13 | <0.001 | 0.1 | 0.08, 0.14 | <0.001 | 0.1 | 0.07, 0.15 | <0.001 |
AXL: axial length, CCT: central corneal thickness, CI: confidence interval, IOP: intraocular pressure, RNFL: retinal nerve fiber layer, MD: mean deviation, VF: visual field
Statistical analysis was performed using the general linear model. Statistically significant values are shown in bold.
* Factors with P < 0.10 in the univariate analysis were included in the multivariate analysis.