Fig 2. Other types of biological networks.

A) Topic model utilizing a patient similarity network. The network guides to find disease subtypes and their features (in the figure, the mutations in genes g₁ and g₂ are selected features for Subtype 1, while Subtype 2 has mutations in g₄ and g₅). Patients can be represented as mixtures of multiple subtypes. B) Disease network. A disease network can be constructed based on shared disease genes or the similarity of disease phenotypes. For example, the disease network on the right has an edge between two diseases if they share the same disease genes or phenotype features.