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. 2015 Sep 4;124(3):265–280. doi: 10.1289/ehp.1409581

Table 7.

Addressing chemical life-cycle impacts (n = 20).

Framework name (reference) Life-cycle impacts addressed? Addressed as a discrete process element? General methods
Life-cycle thinking Life-cycle assessmenta Other (as described)
Goldschmidt 1993
U.S. EPA CTSA (Kincaid et al. 1996)
Rosenberg et al. 2001
Lowell Center for Sustainable Production (Rossi et al. 2006)
MA TURI (Eliason and Morose 2011; MA TURI 2006)
P2OSH (Quinn et al. 2006)
Royal Society of Chemistry (RSC 2007)
TRGS 600 (AGS 2008) b References the use of “tried and tested expert method” for social, environmental, and economic end points.
UNEP Persistent Organic Pollutants Review Committee General Guidance on Alternatives (UNEP 2009)
U.S. EPA DFE Program (Lavoie et al. 2010; U.S. EPA 2011a)
BizNGO (Rossi et al. 2011) c c
German Guide on Sustainable Chemicals (Reihlen et al. 2011)
UCLA Sustainable Policy & Technology Program (Malloy et al. 2011, 2013) Addresses 14 end points associated with life-cycle impacts.
REACH (ECHA 2011) References LCA for comparative evaluation of “far-reaching impacts,” yet states that LCA methods are not designed for the selection of lower-risk alternatives to hazardous chemicals associated with specific uses. Only alternative method offered is the Column Model.
U.S. EPA SNAP Program (U.S. EPA 2011b) Addresses environmental releases and exposure at specific life-cycle stages: manufacture, use, and disposal. Also interested in specific regulatory/programmatic end points, including ozone depletion and greenhouse gas emissions.
European Commission DGE (Gilbert et al. 2012)
Ontario Toxics Use Reduction Program 2012
OSHA 2013
Interstate Chemicals Clearinghouse (IC2 2013) d d
NAS (NRC 2014) e e
aReferencing accepted/standard life-cycle assessment methods. bNot addressed in the typical assessment; part of an “extended assessment” for decisions that have far-reaching implications. cBoth methods mentioned, including their strengths and limitations. dLife-cycle thinking is used in the preliminary and in levels 1 and 2; life-cycle assessment guided by ISO 14040 (ISO 2006) is referred to in level 2 and outlined as the main method in level 3. eUse of life-cycle thinking is recommended before the use of life-cycle analysis to identify upstream and downstream impacts.