Table 4.
Residue | Structural context | KD (μM) |
---|---|---|
Met5 | N-terminus | 385 ± 108 |
Asp6 | N-terminus | 116 ± 25 |
Met7 | N-terminus | 142 ± 30 |
Ser10 | N-terminus | 56 ± 13 |
Leu12 | N-terminus | 10 ± 5 |
Arg13 | N-terminus | 58 ± 13 |
Gln15 | Core | 36 ± 10 |
Tyr17 | Core | 19 ± 9 |
Leu18 | Core | 205 ± 51 |
Val33 | Core | 1041 ± 649 |
Asp36 | A1 tract | 329 ± 93 |
Glu37 | A1 tract | 1549 ± 1168 |
Glu39 | A1 tract | 115 ± 37 |
His40 | Core | 123 ± 23 |
Leu42 | Core | 24 ± 9 |
Ser43 | Core | 166 ± 38 |
Ala64 | Core | 1227 ± 562 |
Asn66 | Core | 1530 ± 958 |
Tyr67 | Core | 245 ± 58 |
Glu68 | Core | 147 ± 29 |
Val74 | Core | 53 ± 14 |
Phe92 | Core | 14 ± 6 |
Glu93 | Core | 329 ± 78 |
Ile94 | Core | 73 ± 17 |
Thr95 | Core | 34 ± 9 |
Leu116 | Core | 101 ± 24 |
Val117 | Core | 61 ± 17 |
Ala118 | Core | 35 ± 9 |
Glu120 | A2 tract | 68 ± 16 |
Glu121 | A2 tract | 101 ± 18 |
Asp122 | A2 tract | 279 ± 76 |
Ala123 | A2 tract | 182 ± 50 |
Glu124 | A2 tract | 614 ± 410 |
Glu126 | A2 tract | 576 ± 471 |
Asp127 | A2 tract | 2162 ± 1612 |
Glu130 | A2 tract | 4258 ± 1986 |