Table 6.
Conservation score of KPBD mutations.The table shows, for each non-synonymous KPBD mutation observed in the dataset, the number of samples carrying the mutation in Africa (AFR), in Southeast Asia (SEA), and a substitution score of the mutation, based on a CCF53P62 substitution matrix; lower values indicate more radical substitutions. Mutations observed in Africa tend to have higher conservation score, whereas in SEA mutations tend to be more radical.
| Mutation | AFR | SEA | CFF53P62 |
|---|---|---|---|
| Q613E | 5 |
1 |
2 |
| Y630F | 2 | 1 | 2 |
| V637I | 2 | 0 | 2 |
| V589I | 2 | 0 | 2 |
| T573S | 2 | 0 | 2 |
| Y493H | 1 | 76 | 2 |
| I416V | 1 | 1 | 2 |
| T593S | 1 | 0 | 2 |
| V520I | 1 | 0 | 2 |
| I416M | 1 | 0 | 2 |
| F395Y | 0 | 1 | 2 |
| S522C | 2 | 1 | 1 |
| E612D | 1 | 0 | 1 |
| C532S | 1 | 0 | 1 |
| R575K | 0 | 3 | 1 |
| A578S | 18 | 0 | 0 |
| A676S | 2 | 3 | 0 |
| V534L | 2 | 0 | 0 |
| R561H | 1 | 24 | 0 |
| A675V | 1 | 18 | 0 |
| H719N | 1 | 8 | 0 |
| P527H | 1 | 5 | 0 |
| A557S | 1 | 0 | 0 |
| R539T | 0 | 63 | 0 |
| I543T | 0 | 34 | 0 |
| G449A | 0 | 7 | 0 |
| F446I | 0 | 7 | 0 |
| A481V | 0 | 4 | 0 |
| F673I | 0 | 3 | 0 |
| P667A | 0 | 2 | 0 |
| F614L | 0 | 1 | 0 |
| S485N | 0 | 1 | 0 |
| P443S | 0 | 1 | 0 |
| C580Y | 2 | 423 | -2 |
| D353Y | 0 | 4 | -2 |
| K438N | 0 | 1 | -2 |
| P553L | 2 | 24 | -3 |
| P441L | 0 | 27 | -3 |
| G538V | 0 | 19 | -3 |
| P574L | 0 | 12 | -3 |
| V568G | 0 | 6 | -3 |
| P667L | 0 | 2 | -3 |
| S459L | 2 | 2 | -4 |
| N537I | 1 | 1 | -4 |
| Q613L | 1 | 0 | -4 |
| D584V | 0 | 3 | -5 |